Loneliness is defined as subjective or perceived social isolation or subjective distress related to the discrepancy between an individual’s desired and actual social connections.1-3 Loneliness is a significant public health concern that is associated with a 40% increased risk of dementia and a 26% increased risk of premature mortality.4, 5 It affects a large segment of the U.S. population, with estimates varying from more than one in three adults to three out of four adults over the age of 45 reporting feeling lonely.
Ventral striatal-hippocampus coupling during reward processing as a (stratification) biomarker for psychotic disorders
Altered ventral striatal (vST) activation to reward expectancy is a well-established intermediate phenotype for psychiatric disorders, specifically schizophrenia. Preclinical research suggests that striatal alterations are related to a reduced inhibition by the hippocampal formation but its role in human transdiagnostic reward-network dysfunctions is not well understood.
The understanding of the neural control of appetite sheds light into the pathogenesis of eating disorders, such as anorexia nervosa and obesity. Both diseases are a result of maladaptive eating behaviors (overeating or undereating) and associated with life-threatening health problems. The fine regulation of appetite involves genetic, physiological and environmental factors which are detected and integrated in the brain by specific neuronal populations. For centuries, the hypothalamus has been the center of attention in the scientific community as a key regulator of appetite.
Cornichon homolog-3 (CNIH3) is an AMPA receptor (AMPAR) auxiliary protein prominently expressed in the dorsal hippocampus (dHPC), a region that plays a critical role in spatial memory and synaptic plasticity. However, effects of CNIH3 on AMPAR-dependent synaptic function and behavior have not been investigated.
Longitudinal Changes of Local Field Potential Oscillations in Nucleus Accumbens and Anterior Limb of the Internal Capsule in Obsessive-Compulsive Disorder
Anterior limb of the internal capsule (ALIC) deep brain stimulation (DBS) shows stable efficacy in refractory obsessive-compulsive disorder (OCD) (1). Recently, several DBS connectivity studies in OCD have investigated the effect of DBS on the structural and functional connectivity in the nucleus accumbens (NAc) and ALIC (2–5). For electrophysiological effects, we attempt to examine the local effects of effective DBS in the NAc/ALIC by long-term recording the local field potentials (LFPs) in a case of OCD.