Increasing evidence suggests that the clinical effects of transcranial magnetic stimulation (TMS) are target-dependent. Within any given symptom, precise targeting of specific brain circuits may improve clinical outcomes. This principle can also be extended across symptoms – stimulation of different circuits may lead to different symptom-level outcomes. This may include targeting different symptoms within the same disorder (such as dysphoria versus anxiety in patients with major depression) or targeting the same symptom across different disorders (such as primary major depression and depression secondary to stroke, traumatic brain injury, epilepsy, multiple sclerosis, or Parkinson’s disease).
Cluster analysis in gambling disorder based on sociodemographic, neuropsychological, and neuroendocrine features regulating energy homeostasis
Publication date: January 2024
Source: Comprehensive Psychiatry, Volume 128
Author(s): Isabel Baenas, Bernat Mora-Maltas, Mikel Etxandi, Ignacio Lucas, Roser Granero, Fernando Fernández-Aranda, Sulay Tovar, Neus Solé-Morata, Mónica Gómez-Peña, Laura Moragas, Amparo del Pino-Gutiérrez, Javier Tapia, Carlos Diéguez, Anna E. Goudriaan, Susana Jiménez-Murcia
The temporal response of changes in renal sodium reabsorption during increased renal sympathetic nerve activity has not been investigated. Central hypovolemia by application of lower-body negative-pressure (LBNP) elicits baroreceptor mediated sympathetic reflexes to maintain arterial blood pressure. We hypothesized, that during 90 min LBNP, the renal sodium retention would increase rapidly, remain increased during intervention, and return to baseline immediately after end of intervention. Go to Source This article was first shared by INDoximity
Stress modulates the activity of various memory systems and can thereby guide behavioral interaction with the environment in an adaptive or maladaptive manner. At the cellular level, a large body of evidence indicates that (nor)adrenaline and glucocorticoid release induced by acute stress-exposure affects synapse function and synaptic plasticity, which are critical substrates for learning and memory. Recent evidence suggests that memories are supported in the brain by sparsely distributed neurons within networks, termed engram cell ensembles.
Chronic and transient loneliness in Western countries: risk factors and association with depression. A two-year follow-up study.
Depression is one of the most prevalent mental disorders and one that contributes substantially to the global burden of disease. The prevalence of the global population with depression in 2015 was 4.4% . Among the main predictors of depressive disorders and symptoms in the elderly, lack or loss of close social contacts and, particularly, feelings of loneliness have a stronger association with depression than do other modifiable risk factors [2–4]. While the relationship between loneliness and depression might be bidirectional, prior research indicates that the prospective association between loneliness and depression is clearly stronger with loneliness as the origin [4,5].