Tagged: Asian Journal of Psychiatry

Adverse events of epidiolex: A real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database

Asian J Psychiatr. 2023 Nov 4;90:103828. doi: 10.1016/j.ajp.2023.103828. Online ahead of print. ABSTRACT Epidiolex, the first FDA-approved drug with cannabis extract, treats Dravet and Lennox-Gastaut syndromes. Using data from the FAERS database between 2018 and 2023, this study analyzed 13,275 Epidiolex-related adverse events. Through computational methods (ROR, PRR, BCPNN, EBGM), we found that real-world adverse reactions largely align with those in Epidiolex’s drug leaflet. However, Seizure cluster, Blood ketone body decrease, Cortical visual impairment, Hyperactive pharyngeal reflex, and Poverty of speech emerged as potential new side effects not previously listed, warranting further attention for drug safety. PMID:37949044 | DOI:10.1016/j.ajp.2023.103828 Go...

Deconstructing the genetic architecture of treatment-resistant schizophrenia in East Asian ancestry

Asian J Psychiatr. 2023 Nov 4;90:103826. doi: 10.1016/j.ajp.2023.103826. Online ahead of print. ABSTRACT BACKGROUND: Treatment-resistant schizophrenia (TRS) affects a substantial proportion of patients who do not respond adequately to antipsychotic medications, yet the underlying biological mechanism remains poorly understood. This study investigates the link between the genetic predisposition to schizophrenia and TRS. METHODS: 857 individuals diagnosed with schizophrenia were divided into TRS (n = 142) and non-TRS (n = 715) based on well-defined TRS criteria. Polygenic risk scores (PRS) were calculated using schizophrenia genome-wide association summary statistics from East-Asian and European ancestry populations. PRS was estimated using both P-value thresholding...

Corrigendum to “Primary health level screening for postpartum depression during well-child visits: Prevalence, associated risk factors, and breastfeeding” [Asian J. Psychiatry 87 (2023) 103701]

Asian J Psychiatr. 2023 Nov 6;90:103829. doi: 10.1016/j.ajp.2023.103829. Online ahead of print. NO ABSTRACT PMID:37939437 | DOI:10.1016/j.ajp.2023.103829 Go to Source This article was first shared by INDoximity