Tagged: American Journal of Ophthalmology

Effectiveness of Propranolol in Preventing Severe Retinopathy of Prematurity: A Comprehensive Systematic Review and Meta-Analysis

One of the most common causes of juvenile blindness that is avoidable is retinopathy of prematurity (ROP). As more extremely preterm newborns survive, its occurrence rises. The development of ROP is influenced by a wide range of circumstances. Propranolol had been proposed as a therapeutic alternative for preterm newborns with pre-existing ROP as well as an early prevention method for ROP. To learn more about the effectiveness of oral propranolol, a meta-analysis was conducted.

RP2-associated X-linked Retinopathy: Clinical Findings, Molecular Genetics, and Natural History in a Large Cohort of Female Carriers

Retinitis Pigmentosa (RP) can be inherited in an autosomal dominant, autosomal recessive or X-linked (XLRP) pattern, exhibiting great phenotypic and genotypic variability. 1-3 XLRP is a severe form of RP, with most affected males presenting with early-onset vision loss (<10 years of age), nyctalopia, nystagmus, severely abnormal or undetectable electroretinogram (ERG) and progression to legal blindness by the 3rd to 4th decade.4-6 RPGR and RP2 disease-causing variants are the commonest causes of XLRP, accounting for 80-90% of cases.