Tagged: American Journal of Geriatric Psychiatry

Review of Religious Variables in Advance Care Planning for End-of-Life Care: Consideration of Faith as a New Construct

The scientific evidence is quite clear that religious communities, religious practices, and religious and spiritual (R/S) values are important social determinants of health and important for “human flourishing” through maintaining and promoting the physical, spiritual and mental health needs of individuals. The data supporting the positive relationship of religion and health are important reminders for physicians and healthcare providers to consider religious beliefs and R/S values as foundational for patient-centered care, especially at end-of-life (EOL).

RISK OF LATE-ONSET DEPRESSION AND COGNITIVE DECLINE: RESULTS FROM INFLAMMATORY PROTEOME ANALYSES IN A PROSPECTIVE POPULATION-BASED COHORT STUDY

Late-onset depression (LOD), a depressive episode occurring for the first time in adults aged 65 years or older, is one of the most common neuropsychiatric disorders among older people.1-3 It has distinctive clinical features differentiating it from other types of depressive disorders, such as recurrent and early-onset depression4, and it has partially overlapping signs and symptoms with mild behavioral impairment5,6 and early-stage dementia.7-9 While distinctive clinical features raise the question of whether different types of depressive disorders present different biological markers, common clinical profiles between LOD and cognitive decline in old age raise the question of whether these two conditions...

Memory Supplements: Television Ads and the Elderly

The Food and Drug Administration’s (FDA) approval in June 2021 of the first new Alzheimer’s disease treatment in 18 years, aducanumab (Aduhelm), has been greeted with excitement and controversy in the media and in the medical community. The American Association of Geriatric Psychiatry (AAGP) has commented thoughtfully about this medication (1).

Improving Interventions for Loneliness and Social Isolation in Late Life: The Potential Role of Positive Affect

Social isolation and loneliness are robust predictors of negative physical and mental health in late life. Loneliness is associated with structural and functional brain abnormalities in the default mode network as well as circuits supporting attention and visual processing.1 With aging, cognition and physical health decline and the need for social support increases. During this vulnerable period, older adults experience shrinkage of social networks and increased social isolation.2 Among non-depressed adults, loneliness is associated with increased risk of physical problems and even mortality.

Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression

Biological changes that accompany the aging process are seen at cellular, organ, and organismal levels and are influenced by epigenetic, genetic, and environmental factors.1 These changes affect brain processes including cognitive, motor, and sensory functions.2 “Accelerated aging” describes when biological aging occurs more rapidly than expected. Individuals with the same chronological age may exhibit different biological ages, and the difference may have clinical implications.1 Accelerated aging, assessed using biological markers such as magnetic resonance imaging (MRI) measures, telomere length, epigenetic markers, or low-grade inflammation,3 occurs in a range of neuropsychiatric disorders, including schizophrenia, anxiety disorders, and depression.

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