Commentary: Locoregional metastasis of adrenocortical carcinoma and lymphadenectomy – Disease clearance or identification of high-risk features?

Given the increased options for systemic treatment of ACC, attention has returned to focus on more effective control of the primary tumor and locoregional disease via development of best practices for surgical management. In ‘Informing Therapeutic Lymphadenectomy: Location of Regional Metastatic Lymph Nodes in Adrenocortical Carcinoma’,1 the authors document locoregional lymph node involvement by ACC from operations performed at a single institution over a 20 year period. While adding to the existing literature, we are reminded of the difficulty in examining this type of data.

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