Role of inflammation in TBI-associated risk for neuropsychiatric disorders: state of the evidence and where do we go from here

In the last decade there has been an increasing awareness that traumatic brain injury (TBI) and concussion substantially increases risk for developing psychiatric disorders. Even mild TBI increases risk for depression and anxiety disorders such as posttraumatic stress disorder (PTSD) by 2-3 fold, predisposing patients to further functional impairment. This strong epidemiological link supports examination of potential mechanisms driving neuropsychiatric symptom development after TBI. One potential mechanism for increased neuropsychiatric symptoms after TBI is via inflammatory processes, as CNS inflammation can last years after initial injury.

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